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REMEDY : BNSSG referral pathways & Joint Formulary

Cancer of Unknown Primary - 2WW

Checked: 01-01-2020 by vicky.ryan Next Review: 11-06-2020

Service Overview

Cancer of Unknown Primary services are available via 2WW for patients with cancer where the primary disease site is not clear. Please note that this service is for patients who have radiological evidence of metastatic disease where there is no clear primary origin of cancer. It is not suitable for patients with concerning symptoms but no evidence of cancer where more a more specific 2WW referral may be more appropriate.

For more information please see:

NICE guidance - Metastatic Malignant Disease of Unknown Primary Origin (CG104) 

Referral Guidance

Referrals to be made via e-Referral using the 2WW proforma (word doc) to UHBristol. If the patient is from the Weston area, the referral gets sent to Acute oncology at WGH to triage and either accept or reject.

For professional queries about suitability of referral please contact the Cancer of Unknown Primary teams on:

UHBristol : 0117 342 1295

Weston: 01934 881080 (acute oncology clinical nurse specialist)


At time of referral please issue the relevant BNSSG 2WW Patient Information Leaflet - COVID-19 edition, which is available in English and 14 additional languages.

There is also an Easy Read version of the leaflet.